Château Sixtine produces wines from Châteauneuf-du-Pape, the Southern Rhône's most prestigious appellation. The winery's flagship Cuvée du Vatican Châteauneuf-du-Pape blends Grenache, Syrah, and Mourvèdre—the classic triumvirate of the region—and has earned recognition from Decanter, Wine Advocate, Wine Spectator, Wine Enthusiast, and Falstaff. A second expression, Cuvée du Vatican Côtes du Rhône, offers a Grenache and Syrah blend from the broader Rhône Valley designation. The Manus Dei Châteauneuf-du-Pape rounds out the portfolio with its own take on the appellation's signature blend. Châteauneuf-du-Pape wines are built on ripe, structured fruit and the distinctive minerality imparted by the region's famous galets—large rounded stones that retain heat and define the terroir. These releases reflect the winery's commitment to the Southern Rhône's traditional winemaking approach.